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Anti-DNMT3A Antibody

Boster Bio Anti-DNMT3A Antibody catalog # A00136. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

DNA (cytosine-5) -methyltransferase 3A; Dnmt3a;2.1.1.37; DNA methyltransferase HsaIIIA; DNA MTase HsaIIIA; M.HsaIIIA; DNMT3A;

Gene Name

DNMT3A

UniProt

Q9Y6K1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide corresponding to residues in Human DNMT3A

Clonality

Polyclonal

Tissue Specificity

Highly expressed in fetal tissues, skeletal muscle, heart, peripheral blood mononuclear cells, kidney, and at lower levels in placenta, brain, liver, colon, spleen, small intestine and lung.

Applications

WB

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Dilution

WB: 1:500-1:1000

Form

Liquid

Function

Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.

Molecular Weight

101858 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A00136

Product MSDS

https://www.bosterbio.com/msds?sku=A00136

Other Gene Names

DNA (cytosine-5) -methyltransferase 3A

Subcellular Location

Nucleus

Protein Name

DNA (cytosine-5) -methyltransferase 3A

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