AMD 3465 (hexahydrobromide)
Product Specifications
UNSPSC Description
AMD 3465 hexahydrobromide (GENZ-644494 hexahydrobromide) is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC50s of 0.75 nM and 18 nM in SupT1 cells; AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM), but has no effect on CCR5-using (R5) viruses.
Target Antigen
CXCR; HIV
Type
Reference compound
Related Pathways
Anti-infection;GPCR/G Protein;Immunology/Inflammation
Applications
COVID-19-anti-virus
Field of Research
Infection; Endocrinology
Assay Protocol
https://www.medchemexpress.com/AMD-3465-hexahydrobromide.html
Solubility
DMSO : 50 mg/mL (ultrasonic)|H2O : ≥ 38 mg/mL
Smiles
[H]Br.[H]Br.[H]Br.[H]Br.[H]Br.[H]Br.C1(CNCC2=CC=C(CN3CCNCCCNCCNCCC3)C=C2)=NC=CC=C1
Molecular Weight
896.07
References & Citations
[1]Hatse S, et al. AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor. Biochem Pharmacol. 2005 Sep 1;70(5):752-61.|[2]Yang L, et al. Blocking CXCR4-mediated cyclic AMP suppression inhibits brain tumor growth in vivo. Cancer Res. 2007 Jan 15;67(2):651-8.Biomed Pharmacother. 2021 Mar 24;138:111476.|J Labelled Comp Radiopharm. 2018 May 15;61(5):438-446. |Patent. US20180263995A1.|Br J Haematol. 2022 Dec 19.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-15971/AMD-3465-hexahydrobromide-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-15971/AMD-3465-hexahydrobromide-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
185991-07-5
Available Sizes
Curated Selection
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