Perindopril

Perindopril (S-9490) is an orally available, long-acting angiotensin-converting enzyme (ACE) inhibitor. Perindopril inhibits inflammatory cell influx and intimal thickening, preserving elastin on the inside of the aorta. Perindopril effectively inhibits experimental abdominal aortic aneurysm (AAA) formation in a rat model and reduces pulmonary vasoconstriction in rats with pulmonary hypertension[1][2][3][4].

Product Specifications

CAS Number

[82834-16-0]

Product Name Alternative

S-9490

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Angiotensin-converting Enzyme (ACE) ; NF-κB; Sirtuin; STAT

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; JAK/STAT Signaling; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Perindopril.html

Purity

99.85

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

O=C([C@H]1N(C([C@@H](N[C@H](C(OCC)=O)CCC)C)=O)[C@@]2([H])CCCC[C@@]2([H])C1)O

Molecular Formula

C19H32N2O5

Molecular Weight

368.47

Precautions

H302, H315, H319, H335

References & Citations

[1]Bhat S A, et al. Angiotensin receptor blockade modulates NFκB and STAT3 signaling and inhibits glial activation and neuroinflammation better than angiotensin-converting enzyme inhibition [J]. Molecular neurobiology, 2016, 53: 6950-6967.|[2]Wei X, et al. Combination of perindopril erbumine and huangqi-danshen decoction protects against chronic kidney disease via sirtuin3/mitochondrial dynamics pathway [J]. Evidence-Based Complementary and Alternative Medicine, 2022, 2022.|[3]Afonso T, et al. Pharmacodynamic evaluation of 4 angiotensin‐converting enzyme inhibitors in healthy adult horses [J]. Journal of veterinary internal medicine, 2013, 27 (5) : 1185-1192.|[4]Thybo N K, et al. Dose-dependent effects of perindopril on blood pressure and small-artery structure [J]. Hypertension, 1994, 23 (5) : 659-666.|[5]Jeffery TK, et al. Perindopril, an angiotensin converting enzyme inhibitor, in pulmonary hypertensive rats: comparative effects on pulmonary vascular structure and function. Br J Pharmacol. 1999 Dec;128 (7) :1407-18.|[6]Xiong F, et al. Inhibition of AAA in a rat model by treatment with ACEI perindopril. J Surg Res. 2014 Jun 1;189 (1) :166-73.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

SIRT3; STAT3

Citation 01

Biomed Pharmacother. 2023 Apr:160:114370.|Phytomedicine. 2024 Oct 28:135:156187.|Biosci Rep. 2021 Oct 29;41 (10) :BSR20211598.|Br J Pharmacol. 2021 Mar;178 (5) :1164-1181.|Evid Based Complement Alternat Med. 2022 May 21;2022:5812105.|Stem Cell Res Ther. 2024 Oct 23;15 (1) :375.