Withaferin A

Withaferin A is a steroidal lactone isolated from Withania somnifera, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding.

Product Specifications

CAS Number

[5119-48-2]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Ferroptosis; NF-κB

Type

Natural Products

Related Pathways

Apoptosis; NF-κB

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Withaferin_A.html

Purity

99.92

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C[C@]([C@](CC[C@@]1(C)[C@@]2([H])CC[C@]1([H])[C@@H]([C@@](O3)([H])CC(C)=C(CO)C3=O)C)([H])[C@@]2([H])C4)(C(C=C5)=O)[C@@]6([C@H]5O)[C@@H]4O6

Molecular Formula

C28H38O6

Molecular Weight

470.60

Precautions

H315, H319, H335

References & Citations

[1]Kaileh M, et al. Withaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity. J Biol Chem. 2007 Feb 16;282 (7) :4253-64. Epub 2006 Dec 6.|[2]Bargagna-Mohan P, et al. The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin. Chem Biol. 2007 Jun;14 (6) :623-34.|[3]Kakar SS, et al. Withaferin A (WFA) inhibits tumor growth and metastasis by targeting ovarian cancer stem cells. Oncotarget. 2017 Aug 10;8 (43) :74494-74505.