Cornuside

Cornuside is a secoiridoid glucoside isolated from the fruit of Cornus officinalis Sieb. et Zucc., which is a traditional oriental medicine for treating inflammatory diseases and invigorating blood circulation. Cornuside inhibits mast cell-mediated allergic response by down-regulating MAPK and NF-κB signaling pathways. Cornuside has anti-allergic effects in vivo and in vitro which suggests a therapeutic application of this agent in inflammatory allergic diseases[1].

Product Specifications

CAS Number

[131189-57-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

NF-κB; p38 MAPK

Type

Natural Products

Related Pathways

MAPK/ERK Pathway; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cornuside.html

Purity

99.99

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC(O)=C(O)C(O)=C1)OCCC(C(C(OC)=O)=COC2OC(C(C(O)C3O)O)OC3CO)C2C=C

Molecular Formula

C24H30O14

Molecular Weight

542.49

Precautions

H302, H315, H319, H335

References & Citations

[1]Li L, et al. Cornuside inhibits mast cell-mediated allergic response by down-regulating MAPK and NF-κB signaling pathways. Biochem Biophys Res Commun. 2016 Apr 29;473 (2) :408-14.