CTTHWGFTLC, CYCLIC (TFA)

CTTHWGFTLC, CYCLIC TFA is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and MMP-9. The IC50 value for MMP-9 is ~8 μM[1].

Product Specifications

UNSPSC

12352209

Target

MMP

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ctthwgftlc-cyclic-tfa.html

Purity

98.91

Solubility

DMSO : ≥ 50 mg/mL

Smiles

O=C(N[C@H]1CC2=CNC3=CC=CC=C23)[C@H](CC4=CN=CN4)NC([C@]([H])([C@@H](C)O)NC([C@]([H])([C@@H](C)O)NC([C@@H](N)CSSC[C@@H](C(O)=O)NC([C@H](CC(C)C)NC([C@]([H])([C@@H](C)O)NC([C@H](CC5=CC=CC=C5)NC(CNC1=O)=O)=O)=O)=O)=O)=O)=O.O=C(C(F)(F)F)O

Molecular Formula

C54H72F3N13O16S2

Molecular Weight

1280.35

References & Citations

[1]Medina OP, et al. Binding of novel peptide inhibitors of type IV collagenases to phospholipid membranes and use in liposome targeting to tumor cells in vitro. Cancer Res. 2001 May 15;61 (10) :3978-85.