Forsythoside B

Forsythoside B is a phenylethanoid glycoside isolated from Forsythia suspensa (Thunb.) Vahl, a Chinese folk medicinal plant for treating inflammatory diseases and promoting blood circulation. Forsythoside B could inhibit TNF-alpha, IL-6, IκB and modulate NF-κB.

Product Specifications

CAS Number

[81525-13-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

NF-κB; TNF Receptor

Type

Natural Products

Related Pathways

Apoptosis; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Forsythoside_B.html

Concentration

10mM

Purity

99.99

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

OC1=C(O)C=C(/C=C/C(O[C@H]2[C@H](O[C@]3([H])O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)[C@@H](O)[C@H](OCCC4=CC=C(O)C(O)=C4)O[C@@H]2CO[C@H]5[C@H](O)[C@](CO)(O)CO5)=O)C=C1

Molecular Formula

C34H44O19

Molecular Weight

756.70

Precautions

H302, H315, H319, H335

References & Citations

[1]Jiang WL, et al. Forsythoside B protects against experimental sepsis by modulating inflammatory factors. Phytother Res. 2012 Jul;26 (7) :981-7.|[2]Jiang WL, et al. Neuroprotective efficacy and therapeutic window of Forsythoside B: in a rat model of cerebral ischemia and reperfusion injury. Eur J Pharmacol. 2010 Aug 25;640 (1-3) :75-81.|[3]Jiang WL, et al. Cardioprotection with forsythoside B in rat myocardial ischemia-reperfusion injury: relation to inflammation response. Phytomedicine. 2010 Jul;17 (8-9) :635-9.