TRi-1

TRi-1 is a potent, specific and irreversible inhibitor of cytosolic thioredoxin reductase 1 (TXNRD1), with an IC50 of 12 nM. TRi-1 has little mitochondrial toxicity for anticancer therapy[1].

Product Specifications

CAS Number

[246020-68-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tri-1.html

Concentration

10mM

Purity

99.91

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

O=[N+](C1=CC=C(OC)N=C1S(=O)(C2=CC=C(Cl)C=C2)=O)[O-]

Molecular Formula

C12H9ClN2O5S

Molecular Weight

328.73

Precautions

H302, H315, H319, H335

References & Citations

[1]Stafford WC, et al. Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy. Sci Transl Med. 2018 Feb 14;10 (428) . pii: eaaf7444.