L-Cycloserine

L-Cycloserine ((S) -4-Amino-3-isoxazolidone) is an oral inhibitor of the enzyme gamma-aminobutyric acid (GABA) transaminase (GABA-t) and branched-chain transaminases in Mycobacterium tuberculosis. L-Cycloserine has anticonvulsant properties and inhibits the synthesis of neurotensin in mouse brains[1][2][3][4].

Product Specifications

CAS Number

[339-72-0]

Product Name Alternative

(S) -Cycloserine; (S) -4-Amino-3-isoxazolidone

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

GABA Receptor; HIV

Type

Natural Products

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/L-Cycloserine.html

Concentration

10mM

Purity

99.50

Solubility

H2O : 200 mg/mL (ultrasonic)

Smiles

O=C1NOC[C@@H]1N

Molecular Formula

C3H6N2O2

Molecular Weight

102.09

Precautions

H302, H315, H319, H335

References & Citations

[1]Tathyana Mar Amorim Franco, et al. Mechanism-Based Inhibition of the Mycobacterium tuberculosis Branched-Chain Aminotransferase by d- and l-Cycloserine. ACS Chem Biol. 2017 May 19;12 (5) :1235-1244.|[2]S H Chung, et al. L-cycloserine: a potent anticonvulsant. Epilepsia. 1984 Jun;25 (3) :353-62.|[3]P Polc, et al. L-cycloserine: behavioural and biochemical effects after single and repeated administration to mice, rats and cats. Neuropharmacology. 1986 Apr;25 (4) :411-8.|[4]K S Sundaram, et al. Inhibition of cerebroside synthesis in the brains of mice treated with L-cycloserine. J Lipid Res. 1985 Apr;26 (4) :473-7.