TC299423
Product Specifications
UNSPSC Description
TC299423 is an orally active, brain-penetrant, selective and potent agonist for α6β2∗ and α4β2∗ nicotinic acetylcholine receptors (nAChRs) with anxiolytic and antinociceptive properties. TC299423 acts primarily through α6β2∗ nAChRs that are implicated in the anxiolytic effects of nicotine. TC299423 elicits reward-related behavior mediated through α6β2∗ nAChRs in hypersensitive α6L90’S mice. TC299423 elicits dopamine release and dose not suppress nicotine self-administration in rats. TC299423 is proming for rasearch of addiction and Parkinson’s disease[1][2].
Target Antigen
nAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tc299423.html
Smiles
C1(/C2=CN=CN=C2)=C\CCNCCC1
Molecular Weight
189.26
References & Citations
[1]Wall TR, et al. TC299423, a Novel Agonist for Nicotinic Acetylcholine Receptors. Front Pharmacol. 2017 Sep 26;8:641.|[2]Post M R. Agonist Binding Studies at Two Subtypes of the Nicotinic Acetylcholine Receptor Involved in Parkinson’s Disease and Addiction[D]. California Institute of Technology, 2016.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-124110/TC299423-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-124110/
Clinical Information
No Development Reported
CAS Number
1975146-56-5
Curated Selection
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