MK 0893

MK 0893 is a potent and selective glucagon receptor antagonist with an IC50 of 6.6 nM.

Product Specifications

CAS Number

[870823-12-4]

UNSPSC

12352005

Target

GCGR

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/mk-0893.html

Purity

99.83

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

ClC1=CC(C2=NN(C(C3=CC4=C(C=C3)C=C(OC)C=C4)=C2)[C@H](C5=CC=C(C=C5)C(NCCC(O)=O)=O)C)=CC(Cl)=C1

Molecular Formula

C32H27Cl2N3O4

Molecular Weight

588.48

References & Citations

[1]Xiong Y, et al. Discovery of a novel glucagon receptor antagonist N-[ (4-{ (1S) -1-[3- (3, 5-dichlorophenyl) -5- (6-methoxynaphthalen-2-yl) -1H-pyrazol-1-yl]ethyl}phenyl) carbonyl]-β-alanine (MK-0893) for the treatment of type II diabetes.J Med Chem. 2012 Jul 12