PARPi-FL

PARPi-FL (Olaparib-bodipy FL) is a small-molecule fluorescent inhibitor of PARP1 that can specifically bind to PARP1. PARPi-FL can be used as a fluorescent imaging agent for tumor detection, diagnosis, and surgical guidance[1][2][3].

Product Specifications

CAS Number

[1380359-84-1]

Product Name Alternative

Olaparib-bodipy FL

UNSPSC

12171500

Target

Fluorescent Dye; PARP

Type

Dye Reagents

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/parpi-fl.html

Purity

99.74

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1NN=C(CC2=CC=C(C(C(N3CCN(CC3)C(CCC4=CC=C5C=C6C(C)=CC(C)=[N]6[B+3]([F-])([N-]54)[F-])=O)=O)=C2)F)C7=C1C=CC=C7

Molecular Formula

C34H32BF3N6O3

Molecular Weight

640.46

References & Citations

[1]Ziadeh T, et al. Poly (ADP-ribose) polymerase inhibitors in prostate cancer: a cornerstone in precision oncology. Pharmacogenomics. 2021 Dec;22 (18) :1237-1250.|[2]Irwin CP, et al. PARPi-FL--a fluorescent PARP1 inhibitor for glioblastoma imaging. Neoplasia. 2014 May;16 (5) :432-40. doi: 10.1016/j.neo.2014.05.005. Epub 2014 Jun 23.|[3]Susanne Kossatz, et al.Detection and delineation of oral cancer with a PARP1 targeted optical imaging agent. Sci Rep. 2016; 6: 21371.