Hexetidine

Hexetidine (NSC-17764) is an orally active antibacterial and antifungal agent with broad antibacterial and antifungal activity. Hexetidine combined with IPBC potentiates strong fungal growth inhibition properties. Hexetidine at concentrations greater than 0.1% can cause oral ulceration. Additionally, Hexetidine improves its plaque inhibiting activities combined with zinc and has been confirmed the effectiveness on purulent wound along with ultrasound. Hexetidine is a promising candidate for research in fungus-related diseases and soft tissue purulent-inflammatory[1][2][3][4][5]

Product Specifications

CAS Number

[141-94-6]

Product Name Alternative

NSC-17764

UNSPSC

12352005

Hazard Statement

H227, H315, H319, H335

Target

Bacterial; Fungal

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Hexetidine.html

Purity

98.0

Solubility

DMSO : 200 mg/mL (ultrasonic; warming; heat to 80°C) |Ethanol : 100 mg/mL (ultrasonic)

Smiles

NC1(C)CN(CC(CC)CCCC)CN(CC(CC)CCCC)C1

Molecular Formula

C21H45N3

Molecular Weight

339.60

Precautions

H227, H315, H319, H335

References & Citations

[1]Afennich F, et al. The effect of hexetidine mouthwash on the prevention of plaque and gingival inflammation: a systematic review.Int J Dent Hyg. 2011 Aug;9 (3) :182-90.|[2]Vallières C, et al. Potentiated inhibition of Trichoderma virens and other environmental fungi by new biocide combinations[J]. Appl Microbiol Biotechnol. 2021 Apr;105 (7) :2867-2875.|[3]Dr. Sandhya Gnanasambandam, et al. Role of supra-gingival plaque in the pathophysiology of periodontitis. World Journal of Pharmaceutical Research. 2024 April 12; 13 (8) : 902-915.|[4]Ivan S. Dragovoz, et al. Comparative Evaluation of Isolated and Complex Use of Hexetidine and Photoditazine in Combination with Ultrasound Therapy in the Treatment of Purulent Wounds under Experimental Conditions[J]. International Journal of Biomedicine. 2022 March 20; 12 (1) :138-141|[5]Gorman SP, et al. The concomitant development of poly (vinyl chloride) -related biofilm and antimicrobial resistance in relation to ventilator-associated pneumonia[J]. Biomaterials. 2001 Oct;22 (20) :2741-7.