MC1742

MC1742 is a potent HDAC inhibitor, with IC50s of 0.1 μM, 0.11 μM, 0.02 μM, 0.007 μM, 0.61 μM, 0.04 μM and 0.1 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, HDAC10 and HDAC11, respectively. MC1742 can increase acetyl-H3 and acetyl-tubulin levels and inhibits cancer stem cells growth. MC1742 can induce growth arrest, apoptosis, and differentiation in sarcoma CSC[1].

Product Specifications

CAS Number

[1776116-74-5]

UNSPSC

12352005

Target

Apoptosis; HDAC

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mc1742.html

Purity

98.95

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=C1N=C(NC(C2=CC=C(C3=CC=CC=C3)C=C2)=C1)SCCCCC(NO)=O

Molecular Formula

C21H21N3O3S

Molecular Weight

395.47

References & Citations

[1]Di Pompo G, et al. Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells. J Med Chem. 2015;58 (9) :4073-4079.