1-Hydroxyphenazine

1-Hydroxyphenazine (Hemipyocyanine; 1-Phenazinol; Hemi-pyocyanin) is an inhibitor for α-Amylase with an IC50 of 3.1 μg/mL[1]. 1-Hydroxyphenazine exhibits anticancer and anti-inflammatory activity against cells A549, 1321N1 and RAW264.7, antifungal and antibacterial activity against strains Candida albicans, Aspergillus fumigatus, Escherichia coli and Xanthomonas campestris[2][3][4][5].

Product Specifications

CAS Number

[528-71-2]

Product Name Alternative

Hemipyocyanine; 1-Phenazinol; Hemi-pyocyanin

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Amylases; Bacterial

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Infection; Metabolic Disease; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/1-hydroxyphenazine.html

Purity

99.80

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=CC=CC2=NC3=CC=CC=C3N=C21

Molecular Formula

C12H8N2O

Molecular Weight

196.20

Precautions

H302, H315, H319, H335

References & Citations

[1]Nguyen TH, et al., Novel α-Amylase Inhibitor Hemi-Pyocyanin Produced by Microbial Conversion of Chitinous Discards. Mar Drugs. 2022 Apr 23;20 (5) :283. |[2]McFarland AJ, et al., Inhibition of autophagy by 3-methyladenine protects 1321N1 astrocytoma cells against pyocyanin- and 1-hydroxyphenazine-induced toxicity. Arch Toxicol. 2012 Feb;86 (2) :275-84|[3]Xiao J, et al., Anti-Inflammatory Effects of an Extract from Pseudomonas aeruginosa and Its Purified Product 1-Hydroxyphenazine on RAW264.7 Cells. Curr Microbiol. 2021 Jul;78 (7) :2762-2773.|[4]Prabhu MS, et al., Purification and molecular and biological characterisation of the 1-hydroxyphenazine, produced by an environmental strain of Pseudomonas aeruginosa. World J Microbiol Biotechnol. 2014 Dec;30 (12) :3091-9.|[5]Kerr JR, et al., Pseudomonas aeruginosa pyocyanin and 1-hydroxyphenazine inhibit fungal growth. J Clin Pathol. 1999 May;52 (5) :385-7.