GR-28
GR-28 is an inhibitor for small C-terminal domain phosphatase 1 (SCP1) . GR-28 inhibits the transcriptional activity of repressor element-1 silencing transcription factor (REST), inhibits the proliferation of glioblastoma cells (IC50 is 2.9 and 10.1 µM, for cells A172 and T98G) [1].
Product Specifications
UNSPSC
12352005
Target
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gr-28.html
Smiles
O=C(NCCCNC(C1=CC=C(C2=CC=CC=C2OC)C=C1)=O)C3=CC4=CC=CC=C4S3(=O)=O
Molecular Formula
C26H24N2O5S
Molecular Weight
476.54
References & Citations
[1]Panina SB, et al., Targeting of REST with rationally-designed small molecule compounds exhibits synergetic therapeutic potential in human glioblastoma cells. BMC Biol. 2024 Apr 12;22 (1) :83.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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