Oxidopamine (hydrobromide)

Oxidopamine (6-OHDA) hydrobromide is an antagonist of the neurotransmitter dopamine. Oxidopamine hydrobromide is a widely used neurotoxin and selectively destroys dopaminergic neurons. Oxidopamine hydrobromide promotes COX-2 activation, leading to PGE2 synthesis and pro-inflammatory cytokine IL-1β secretion. Oxidopamine hydrobromide can be used for the research of Parkinson’s disease (PD), attention-deficit hyperactivity disorder (ADHD), and Lesch-Nyhan syndrome[1][2][3][4].

Product Specifications

CAS Number

[636-00-0]

Product Name Alternative

6-Hydroxydopamine hydrobromide; 6-OHDA hydrobromide

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Autophagy; Caspase; COX; Dopamine Receptor; Interleukin Related; Mitophagy; p38 MAPK; PGE synthase

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; MAPK/ERK Pathway; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Oxidopamine-hydrobromide.html

Purity

99.65

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 20 mg/mL (ultrasonic)

Smiles

OC1=CC(CCN)=C(O)C=C1O.[H]Br

Molecular Formula

C8H12BrNO3

Molecular Weight

250.09

Precautions

H302, H315, H319, H335

References & Citations

[1]Fujita H et al. Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt pathway. Brain Res. 2006 Oct 3;1113 (1) :10-23.|[2]Soto-Otero R et al. Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants: potential implication in relation to the pathogenesis of Parkinson's disease. J Neurochem. 2000 Apr;74 (4) :1605-12.|[3]Jin F, et al. Neuroprotective effect of resveratrol on 6-OHDA-induced Parkinson's disease in rats. Eur J Pharmacol. 2008 Dec 14;600 (1-3) :78-82. |[4]Kang X, et al. Cyclooxygenase-2 contributes to oxidopamine-mediated neuronal inflammation and injury via the prostaglandin E2 receptor EP2 subtype. Sci Rep. 2017 Aug 25;7 (1) :9459.|[5]Jin F, et al. Neuroprotective effect of resveratrol on 6-OHDA-induced Parkinson's disease in rats[J]. European journal of pharmacology, 2008, 600 (1-3) : 78-82.|[6]Lee C S, et al. Dopaminergic neuronal degeneration and motor impairments following axon terminal lesion by intrastriatal 6-hydroxydopamine in the rat[J]. Neuroscience, 1996, 72 (3) : 641-653.|[7]Ryan RE, et al. Dose-related neuroprotective effects of chronic nicotine in 6-hydroxydopamine treated rats, and loss of neuroprotection in alpha4 nicotinic receptor subunit knockout mice. Br J Pharmacol. 2001 Apr;132 (8) :1650-6.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Caspase 3; Caspase 8; Caspase 9; COX-2; IL-1

Citation 01

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