Dihydro-β-erythroidine (hydrobromide)
Product Specifications
UNSPSC Description
Dihydro-β-erythroidine (DHβE) hydrobromide is a potent, orally active, and competitive antagonist of neuronal nAChRs. Dihydro-β-erythroidine hydrobromide shows selectivity for α4β4 and α4β2 nAChRs, with IC50s of 0.19 and 0.37 μM, respectively. Antidepressant-like activities[1][2][3].
Target Antigen
nAChR
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dihydro-β-erythroidine-hydrobromide.html
Purity
99.84
Solubility
DMSO : 8 mg/mL (ultrasonic;warming)|H2O : ≥ 100 mg/mL
Smiles
CO[C@@H]1C[C@]23C(CC4=O)=C(CO4)CCN2CCC3=CC1.Br
Molecular Weight
356.25
References & Citations
[1]Harvey SC, et al. Multiple determinants of dihydro-beta-erythroidine sensitivity on rat neuronal nicotinic receptor alpha subunits. J Neurochem. 1996 Nov;67(5):1953-9.|[2]Tabbara RI, et al. Nicotine enhances responding for conditioned reinforcement via α4β2 nicotinic acetylcholine receptors in the ventral tegmental area, but not the nucleus accumbens or the prefrontal cortex. Neuropharmacology. 2019 Apr;148:68-76.|[3]Clementson S, et al. Enantioselective Total Synthesis of (+)-Dihydro-β-erythroidine. J Am Chem Soc. 2019 Jun 5;141(22):8783-8786.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-107670/Dihydro-β-erythroidine-hydrobromide-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-107670/Dihydro-β-erythroidine-hydrobromide-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
29734-68-7
Available Sizes
Curated Selection
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