RBN-3143
RBN-3143 is a potent and NAD+-competitive catalytic PARP14 inhibitor with an IC50 value of 4 nM. RBN-3143 inhibits PARP14-mediated ADP-ribosylation and stabilizes PARP14 in cell lines. RBN-3143 can be used in research of lung inflammation[1].
Product Specifications
CAS Number
[2360853-16-1]
UNSPSC
12352005
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/rbn-3143.html
Purity
99.29
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1NC(CSC2CCOCC2)=NC3=CC(OCC4CCN(CC4)C(C)=O)=CC(F)=C13
Molecular Formula
C22H28FN3O4S
Molecular Weight
449.54
References & Citations
[1]Niepel M, et, al. The PARP14 inhibitor RBN-3143 suppresses lung inflammation in preclinical models. European Respiratory Journal 2022 60: 4642.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
PARP1; PARP10; PARP14; PARP15; PARP2; PARP3; PARP4
Available Sizes
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