Nedocromil

Nedocromil suppresses the action or formation of multiple mediators, including histamine, leukotriene C4 (LTC4), and prostaglandin D2 (PGD2) .

Product Specifications

CAS Number

[69049-73-6]

Product Name Alternative

FPL 59002

UNSPSC

12352005

Hazard Statement

H319

Target

Histamine Receptor; Leukotriene Receptor; Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Nedocromil.html

Concentration

10mM

Purity

98.75

Solubility

DMSO : 16.67 mg/mL (ultrasonic)

Smiles

O=C(C1=CC(C2=CC3=C(N(CC)C(C(O)=O)=CC3=O)C(CCC)=C2O1)=O)O

Molecular Formula

C19H17NO7

Molecular Weight

371.34

Precautions

H319

References & Citations

[1]Wells E, et al. Characterization of primate bronchoalveolar mast cells. II. Inhibition of histamine, LTC4, and PGD2 release from primate bronchoalveolar mast cells and a comparison with rat peritoneal mastcells. J Immunol. 1986 Dec 15;137 (12) :3941-5.|[2]Myocardial remodeling in diabetic cardiomyopathy associated with cardiac mast cell activation. Huang ZG, et al. PLoS One. 2013;8 (3) :e60827.