Spiramide

Spiramide (AMI-193) is a potent and selective antagonist of 5-HT2 and dopamine D2 receptor, with Kis of 2 nM and 3 nM, respectively. Spiramide has >2000-fold selectivity for 5-HT2 versus 5-HT1C (Ki=4300 nM) receptors. Spiramide exhibits antipsychotic activity[1][2][3].

Product Specifications

CAS Number

[510-74-7]

Product Name Alternative

AMI-193

UNSPSC

12352005

Target

5-HT Receptor; Dopamine Receptor

Type

Natural Products

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/spiramide.html

Concentration

10mM

Purity

99.23

Solubility

DMSO : 20 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1NCN(C2=CC=CC=C2)C13CCN(CCCOC4=CC=C(F)C=C4)CC3

Molecular Formula

C22H26FN3O2

Molecular Weight

383.46

References & Citations

[1]Ismaiel AM, et, al. Antagonism of 1- (2,5-dimethoxy-4-methylphenyl) -2-aminopropane stimulus with a newly identified 5-HT2- versus 5-HT1C-selective antagonist. J Med Chem. 1993 Aug 20;36 (17) :2519-25.|[2]Czoty PW, et, al. Behavioral effects of AMI-193, a 5-HT (2A) - and dopamine D (2) -receptor antagonist, in the squirrel monkey. Pharmacol Biochem Behav. 2000 Oct;67 (2) :257-64.|[3]Kjellberg B, et, al. Partial restoration by a neuroleptic (spiramide) of items of grooming behaviour suppressed by amphetamine. Arch Int Pharmacodyn Ther. 1974 Jul;210 (1) :61-6.