Eleutherin

Eleutherin is a type of naphthoquinone derivative with the protective effect against the injury ofhuman umbilical vein endothelial cells (HUVECs), which can be isolated from the edible bulbs of Eleutherine americana (Hong-Cong) [1].

Product Specifications

CAS Number

[478-36-4]

Product Name Alternative

(+) -Eleutherin

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Topoisomerase

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/eleutherin.html

Purity

99.22

Solubility

DMSO : 14.29 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=C2[C@@H](C)O[C@@H](C)C1)C3=C(C2=O)C(OC)=CC=C3

Molecular Formula

C16H16O4

Molecular Weight

272.30

Precautions

H302, H315, H319, H335

References & Citations

[1]Castro ALG, et, al. Evaluation of the genotoxicity and mutagenicity of isoeleutherin and eleutherin isolated from Eleutherine plicata herb. using bioassays and in silico approaches. Arabian Journal of Chemistry. Volume 14, Issue 4, April 2021, 103084.|[2]Krishnan P, et, al. Novel mechanisms of DNA topoisomerase II inhibition by pyranonaphthoquinone derivatives-eleutherin, alpha lapachone, and beta lapachone. Biochem Pharmacol. 2000 Nov 1;60 (9) :1367-79.|[3]Chen D, et al. New naphtoquinones derivatives from the edible bulbs of Eleutherine americana and their protective effect on the injury of human umbilical vein endothelial cells. Fitoterapia. 2019 Jan;132:46-52.