Isovaleric acid
Product Specifications
UNSPSC Description
Isovaleric acid is an oral active short-chain fatty acid that inhibits osteoclast differentiation by stimulating AMPK phosphorylation and promotes colonic smooth muscle relaxation by activating the cAMP/PKA pathway. Isovaleric acid can be used in research on skeletal diseases (such as osteoporosis) and intestinal disorders[1][2][3][4].
Target Antigen
AMPK; Endogenous Metabolite; PKA
Type
Natural Products
Related Pathways
Epigenetics;Metabolic Enzyme/Protease;PI3K/Akt/mTOR;Stem Cell/Wnt;TGF-beta/Smad
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/3-Methylbutanoic_acid.html
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)
Smiles
CC(C)CC(O)=O
Molecular Weight
102.13
References & Citations
[1]Ackman RG, et al. Birthweights in the Faroe Islands: possible role of isovaleric acid. J Intern Med. 1989 Feb;225(2):73-5.|[2]Ribeiro C A J, et al. Isovaleric acid reduces Na+, K+-ATPase activity in synaptic membranes from cerebral cortex of young rats[J]. Cellular and molecular neurobiology, 2007, 27: 529-540.|[3]Cho K M, et al. Isovaleric acid ameliorates ovariectomy‐induced osteoporosis by inhibiting osteoclast differentiation[J]. Journal of Cellular and Molecular Medicine, 2021, 25(9): 4287-4297.|[4]Blakeney BA, et al. Branched Short-Chain Fatty Acid Isovaleric Acid Causes Colonic Smooth Muscle Relaxation via cAMP/PKA Pathway. Dig Dis Sci. 2019 May;64(5):1171-1181.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-W012980/Isovaleric-acid-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-W012980/Isovaleric-acid-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
503-74-2
Available Sizes
Curated Selection
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