ZMF-24

ZMF-24 is an anti-triple-negative breast cancer (TNBC) agent with IC50 values of 0.22 μM and 0.44 μM against TNBC proliferation in BT-549 cells and MDA-MB-231 cells, respectively. ZMF-24 inhibits Eukaryotic translation initiation factor 3 subunit D (EIF3D) that disrupts the energy supply of TNBC by inhibiting glycolysis and further induces profound TNBC apoptosis by stimulating persistent ER stress[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Eukaryotic Initiation Factor (eIF)

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/zmf-24.html

Smiles

O=C(CC1=CC=C(C=C1)NC(/C=C/C2=CC=CC=C2)=O)O[C@@H](CC3(C4)[C@H](OC4=O)/C=C(CC/C=C(C)/C)\C)C=CC3=O

Molecular Formula

C35H37NO6

Molecular Weight

567.67

References & Citations

[1]Zhao X, et al. Design, synthesis and biological evaluation of plant-derived miliusol derivatives achieve TNBC profound regression in vivo. Eur J Med Chem. 2024 Sep 18;279:116882.