ZMF-24
Product Specifications
UNSPSC Description
ZMF-24 is an anti-triple-negative breast cancer (TNBC) agent with IC50 values of 0.22 μM and 0.44 μM against TNBC proliferation in BT-549 cells and MDA-MB-231 cells, respectively. ZMF-24 inhibits Eukaryotic translation initiation factor 3 subunit D (EIF3D) that disrupts the energy supply of TNBC by inhibiting glycolysis and further induces profound TNBC apoptosis by stimulating persistent ER stress[1].
Target Antigen
Apoptosis; Eukaryotic Initiation Factor (eIF)
Type
Reference compound
Related Pathways
Apoptosis;Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/zmf-24.html
Smiles
O=C(CC1=CC=C(C=C1)NC(/C=C/C2=CC=CC=C2)=O)O[C@@H](CC3(C4)[C@H](OC4=O)/C=C(CC/C=C(C)/C)\C)C=CC3=O
Molecular Weight
567.67
References & Citations
[1]Zhao X, et al. Design, synthesis and biological evaluation of plant-derived miliusol derivatives achieve TNBC profound regression in vivo. Eur J Med Chem. 2024 Sep 18;279:116882.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-168106/ZMF-24-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-168106/
Clinical Information
No Development Reported
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