ARN25068
Product Specifications
UNSPSC Description
ARN25068 is a sub-micromolar inhibitor of the three protein kinases, GSK-3β, FYN and DYRK1A to tackle tau hyperphosphorylation[1].
Target Antigen
DYRK; GSK-3
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/arn25068.html
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
C1(CNC2=NC(NC3=CC(C4CC4)=NN3)=C5SC=CC5=N2)=CC=CC=C1
Molecular Weight
362.45
References & Citations
[1]Stefania Demuro, et al. ARN25068, a versatile starting point towards triple GSK-3β/FYN/DYRK1A inhibitors to tackle tau-related neurological disorders. Eur J Med Chem. 2022 Feb 5;229:114054.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-144290/ARN25068-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-144290/ARN25068-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2649882-80-2
Available Sizes
Curated Selection
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