AMPK-IN-1

AMPK-IN-1 is an activator of AMPK (EC50: 551 nM for isoform α2β2γ1) . AMPK-IN-1 leads to eEF2 phosphorylation in a mTORC1-independent way[1][2][3].

Product Specifications

CAS Number

[1219739-95-3]

UNSPSC

12352005

Target

AMPK

Type

Reference compound

Related Pathways

Epigenetics; PI3K/Akt/mTOR

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/ampk-in-1.html

Purity

99.91

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(O)C1=CC(OC2=NC3=CC(Cl)=C(C4=CC5=C(C=C4)C=CN5C)C=C3N2)=CC=C1C

Molecular Formula

C24H18ClN3O3

Molecular Weight

431.87

References & Citations

[1]Ngoei KRW, et al. Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK α2β2γ1 by the Glucose Importagog SC4. Cell Chem Biol. 2018 Jun 21;25 (6) :728-737.e9. |[2]Cao Y, et al. Novel cyclic benzimidazole derivatives useful anti-diabetic agents. Patent. WO2010036613. |[3]Johanns M, et al. Direct and indirect activation of eukaryotic elongation factor 2 kinase by AMP-activated protein kinase. Cell Signal. 2017 Aug;36:212-221.