U-83836E

U-83836E (PNU-83836E) is a compound with anti-inflammatory and antioxidant activities that reduces lung inflammation inhibiting oxidative stress and ROS production. U-83836E has shown potential for treating asthma and lung inflammation in animal models[1][2].

Product Specifications

CAS Number

[137018-55-4]

Product Name Alternative

PNU-83836E

UNSPSC

12352005

Target

Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/u-83836e.html

Purity

98.59

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

OC1=C(C)C(C)=C2C(CC[C@](C)(CN3CCN(C4=NC(N5CCCC5)=NC(N6CCCC6)=C4)CC3)O2)=C1C.Cl.Cl

Molecular Formula

C30H46Cl2N6O2

Molecular Weight

593.63

References & Citations

[1]Johnson H G, et al. Late phase bronchoconstriction and eosinophilia as well as methacholine hyperresponsiveness in Ascaris-sensitive rhesus monkeys were reversed by oral administration of U-83836E[J]. International archives of allergy and immunology, 1993, 100 (4) : 362-366.|[2]Camins A, et al. U-83836E prevents kainic acid-induced neuronal damage[J]. Naunyn-Schmiedeberg's archives of pharmacology, 1998, 357: 413-418.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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