Phenacetin-d5

Phenacetin-d5 is the deuterium labeled Phenacetin. Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats[1][2][3].

Product Specifications

CAS Number

[69323-74-6]

Product Name Alternative

Acetophenetidin-d5

UNSPSC

12352005

Hazard Statement

H302, H350

Target

COX

Type

Isotope-Labeled Compounds

Related Pathways

Immunology/Inflammation

Field of Research

Inflammation/Immunology

Concentration

10mM

Purity

99.51

Solubility

DMSO : ≥ 100mg/mL|H2O : 0.67mg/mL (ultrasonic)

Smiles

CC(NC1=CC=C(C=C1)OC([2H])([2H])C([2H])([2H])[2H])=O

Molecular Formula

C10H8D5NO2

Molecular Weight

184.25

Precautions

H302, H350

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Chandrasekharan NV, et al. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc Natl Acad Sci U S A. 2002 Oct 15;99 (21) :13926-31.|[3]Xiao-Meng He, et al. Effects of long-term smoking on the activity and mRNA expression of CYP isozymes in rats. J Thorac Dis. 2015 Oct; 7 (10) : 1725–1731.|[4]Na Gao, et al. Inhibition of Baicalin on Metabolism of Phenacetin, a Probe of CYP1A2, in Human Liver Microsomes and in Rats. PLoS One. 2014; 9 (2) : e89752.