KU-55933
KU-55933 is a potent ATM inhibitor with an IC50 and Ki of 12.9 and 2.2 nM, respectively, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR.
Product Specifications
CAS Number
[587871-26-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
ATM/ATR; Autophagy
Type
Reference compound
Related Pathways
Autophagy; Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/KU-55933.html
Concentration
10mM
Purity
99.92
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1C=C(OC(C2=C3SC4=C(SC3=CC=C2)C=CC=C4)=C1)N5CCOCC5
Molecular Formula
C21H17NO3S2
Molecular Weight
395.49
Precautions
H302, H315, H319, H335
References & Citations
[1]Hickson I, et al. Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res. 2004 Dec 15;64 (24) :9152-9|[2]Khalil HS, et al. Pharmacological inhibition of ATM by KU55933 stimulates ATM transcription.Exp Biol Med (Maywood) . 2012 Jun;237 (6) :622-34. Epub 2012 Jun 22.|[3]Kim YD, et al. Orphan nuclear receptor SHP negatively regulates growth hormone-mediated induction of hepatic gluconeogenesis through inhibition of STAT5 transactivation.J Biol Chem. 2012 Sep 12.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ATM
Available Sizes
Curated Selection
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