KU-55933

KU-55933 is a potent ATM inhibitor with an IC50 and Ki of 12.9 and 2.2 nM, respectively, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR.

Product Specifications

CAS Number

[587871-26-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

ATM/ATR; Autophagy

Type

Reference compound

Related Pathways

Autophagy; Cell Cycle/DNA Damage; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/KU-55933.html

Concentration

10mM

Purity

99.92

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1C=C(OC(C2=C3SC4=C(SC3=CC=C2)C=CC=C4)=C1)N5CCOCC5

Molecular Formula

C21H17NO3S2

Molecular Weight

395.49

Precautions

H302, H315, H319, H335

References & Citations

[1]Hickson I, et al. Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res. 2004 Dec 15;64 (24) :9152-9|[2]Khalil HS, et al. Pharmacological inhibition of ATM by KU55933 stimulates ATM transcription.Exp Biol Med (Maywood) . 2012 Jun;237 (6) :622-34. Epub 2012 Jun 22.|[3]Kim YD, et al. Orphan nuclear receptor SHP negatively regulates growth hormone-mediated induction of hepatic gluconeogenesis through inhibition of STAT5 transactivation.J Biol Chem. 2012 Sep 12.