DBeQ

DBeQ is a selective, potent, reversible, and ATP-competitive p97 inhibitor, with an IC50 value of 1.5 μM and 1.6 μM for p97 (wt) and p97 (C522A), respectively; DBeQ also inhibits Vps4 with an IC50 of 11.5 μM.

Product Specifications

CAS Number

[177355-84-9]

Product Name Alternative

JRF 12

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Autophagy; p97

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/DBeQ.html

Purity

99.68

Solubility

DMSO : 35.71 mg/mL (ultrasonic)

Smiles

C1(NCC2=CC=CC=C2)=NC(NCC3=CC=CC=C3)=C4C=CC=CC4=N1

Molecular Formula

C22H20N4

Molecular Weight

340.42

Precautions

H302, H315, H319, H335

References & Citations

[1]Chou TF, et al.Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways. Proc Natl Acad Sci U S A. 2011 Mar 22;108 (12) :4834-9.|[2]Zhang Y, et al. The AAA ATPase Vps4 Plays Important Roles in Candida albicans Hyphal Formation and is Inhibited by DBeQ. Mycopathologia. 2016 Jun;181 (5-6) :329-39.