Ursonic acid

Ursolic acid is a naturally occurring triterpenoid that has orally active. Ursolic acid induces the apoptosis of human cancer cells through multiple signaling pathways. Ursolic acid has anti-inflammatory and anticarcinogenic activity[1][2].

Product Specifications

CAS Number

[6246-46-4]

Product Name Alternative

3-Ketoursolic acid

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Endogenous Metabolite; NF-κB

Type

Natural Products

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Ursonic-acid.html

Purity

99.88

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 80°C) |H2O : < 0.1 mg/mL

Smiles

CC1(C)C(CC[C@]2(C)[C@@]3([H])CC=C4[C@]5([H])[C@@H](C)[C@H](C)CC[C@@](C(O)=O)5CC[C@](C)4[C@@](C)3CC[C@@]12[H])=O

Molecular Formula

C30H46O3

Molecular Weight

454.68

Precautions

H302, H315, H319, H335

References & Citations

[1]Gai, L., Cai, N., Wang, L., Xu, X. & Kong, X. Ursolic acid induces apoptosis via Akt/NF-kappaB signaling suppression in T24 human bladder cancer cells. Molecular medicine reports 7, 1673-1677, doi:10.3892/mmr.2013.1364 (2013) .|[2]Manu, K. A. & Kuttan, G. Ursolic acid induces apoptosis by activating p53 and caspase-3 gene expressions and suppressing NF-kappaB mediated activation of bcl-2 in B16F-10 melanoma cells. International immunopharmacology 8, 974-981, doi:10.1016/j.intimp.2008.02.013 (2008) .|[3]Saravanan R, et al. Protective effect of ursolic acid on ethanol-mediated experimental liver damage in rats. Life Sci. 2006 Jan 11;78 (7) :713-8.