Prochloraz

Prochloraz is an imidazole antifungal. Prochloraz is as an estrogen receptor (ER) and androgen receptor (AR) antagonist and an aromatase inhibitor with IC50 values of 25 μM, 4 μM and 0.3 μM, respectively. Prochloraz is able to activate the aryl hydrocarbon receptor (AhR) having an EC50 of 1 μM[1][2].

Product Specifications

CAS Number

[67747-09-5]

Product Name Alternative

BTS 40542

UNSPSC

12352005

Hazard Statement

H302, H410

Target

Androgen Receptor; Aryl Hydrocarbon Receptor; Estrogen Receptor/ERR; Fungal

Type

Reference compound

Related Pathways

Anti-infection; Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Infection; Endocrinology

Assay Protocol

https://www.medchemexpress.com/prochloraz.html

Purity

99.85

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(N1C=CN=C1)N(CCC)CCOC2=C(Cl)C=C(Cl)C=C2Cl

Molecular Formula

C15H16Cl3N3O2

Molecular Weight

376.67

Precautions

H302, H410

References & Citations

[1]E Antignac, et al. Prochloraz as potent inhibitor of benzo[a]pyrene metabolism and mutagenic activity in rat liver fractions. Toxicol Lett. 1990 Dec;54 (2-3) :309-15.|[2]Anne Marie Vinggaard, et al. Prochloraz: an imidazole fungicide with multiple mechanisms of action. Int J Androl. 2006 Feb;29 (1) :186-92.