Clitocine

Clitocine, an adenosine nucleoside analog isolated from mushroom, is a potent and efficacious readthrough agent. Clitocine acts as a suppressor of nonsense mutations and can induce the production of p53 protein in cells harboring p53 nonsense-mutated alleles. Clitocine can induce apoptosis in multidrug-resistant human cancer cells by targeting Mcl-1. Anticancer activity[1][2].

Product Specifications

CAS Number

[105798-74-1]

Product Name Alternative

CA-074Me,T-Type calcium channel inhibitor

UNSPSC

12352005

Target

Apoptosis; Bcl-2 Family

Type

Natural Products

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/clitocine.html

Purity

95.88

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](NC2=C([N+]([O-])=O)C(N)=NC=N2)O1

Molecular Formula

C9H13N5O6

Molecular Weight

287.23

References & Citations

[1]Friesen WJ, et al. The nucleoside analog clitocine is a potent and efficacious readthrough agent. RNA. 2017;23 (4) :567-577.|[2]Sun JG, et al. Clitocine potentiates TRAIL-mediated apoptosis in human colon cancer cells by promoting Mcl-1 degradation. Apoptosis. 2016;21 (10) :1144-1157.