Lanadelumab
Lanadelumab (SHP643) is a human IgG1 monoclonal antibody against plasma kallikrein (pKal) with an Ki value of 0.12 nM. Lanadelumab inhibits both free and HMWK (high molecular weight kininogen) -bound pKal. Lanadelumab has the potential for the research of hereditary angioedema[1][2].
Product Specifications
CAS Number
[1426055-14-2]
Product Name Alternative
SHP643; DX-2930; X124-G01
UNSPSC
12352203
Target
Kallikrein
Type
Inhibitory Antibodies
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/lanadelumab.html
Purity
99.90
Solubility
H2O
Smiles
[Lanadelumab]
Molecular Weight
(145.72 kDa)
References & Citations
[1]Riedl MA, et al. Lanadelumab demonstrates rapid and sustained prevention of hereditary angioedema attacks. Allergy. 2020 Nov;75 (11) :2879-2887.|[2]Kenniston JA, et al. Inhibition of plasma kallikrein by a highly specific active site blocking antibody. J Biol Chem. 2014 Aug 22;289 (34) :23596-608.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Launched
Available Sizes
Curated Selection
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