Atrasentan
Product Specifications
UNSPSC Description
Atrasentan (ABT-627) is an endothelin receptor antagonist with IC50 of 0.0551 nM for ETA[1].
Target Antigen
Endothelin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Endocrinology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Atrasentan.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@H]1[C@H](C2=CC=C(OC)C=C2)N(CC(N(CCCC)CCCC)=O)C[C@@H]1C3=CC=C(OCO4)C4=C3)O.[S].[R].[R]
Molecular Weight
542.69
References & Citations
[1]Yuyama H, et al. Superiority of YM598 over atrasentan as a selective endothelin ETA receptor antagonist. Eur J Pharmacol. 2004 Sep 13;498(1-3):171-7.|[2]Banerjee S, et al. In vitro and in vivo molecular evidence for better therapeutic efficacy of ABT-627 and taxotere combination in prostate cancer. Cancer Res. 2007 Apr 15;67(8):3818-26.|[3]Weiss J, et al. Interaction potential of the endothelin-A receptor antagonist atrasentan with drug transporters and drug-metabolising enzymes assessed in vitro. Cancer Chemother Pharmacol. 2011 Oct;68(4):1093-8.Commun Biol. 2022 Jul 28;5(1):750.|Eur J Pharmacol. 2019 Mar 12;852:142-150.|Department Veterinary Clinical Medicine. University of Illinois. 2015.|J Vet Intern Med. 2015 Nov;29(6):1584-94.|Mol Immunol. 2019 Oct;114:10-18.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-15403/Atrasentan-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-15403/Atrasentan-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
173937-91-2
Available Sizes
Curated Selection
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