KG5
KG5 is an orally active dual PDGFRβ and B-Raf allosteric inhibitor. KG5 also inhibits Flt3, KIT and c-Raf. KG5 has anticancer, antiangiogenic activities[1].
Product Specifications
CAS Number
[877874-85-6]
UNSPSC
12352005
Target
C-Kit; FLT3; PDGFR; Raf
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kg5.html
Purity
99.79
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CSC1=NC(OC2=CC=C(C=C2)C3=NN=C(N3)NC4=CC=CC(C(F)(F)F)=C4)=CC(N)=N1
Molecular Formula
C20H16F3N7OS
Molecular Weight
459.45
References & Citations
[1] Eric A Murphy, et al. Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFRbeta/B-RAF. Proc Natl Acad Sci U S A. 2010 Mar 2;107 (9) :4299-304.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
B-Raf; C-Raf; PDGFRα; PDGFRβ
Available Sizes
Curated Selection
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