Tanimilast
Tanimilast (CHF-6001) is an orally active and selective phosphodiesterase 4 inhibitor (IC50=0.026 nM) with robust anti-inflammatory activity and suitable for topical pulmonary administration. Tanimilast increases cellular cAMP levels, and inhibits NF-κB signaling pathway. Tanimilast is used for the research of obstructive lung diseases[1][2].
Product Specifications
Product Name Alternative
CHF-6001
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
CCR; CXCR; Interleukin Related; NF-κB; Phosphodiesterase (PDE) ; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tanimilast.html
Concentration
10mM
Purity
99.71
Solubility
DMSO : 200 mg/mL (ultrasonic; warming)
Smiles
O=C(O[C@H](C1=CC=C(OC(F)F)C(OCC2CC2)=C1)CC3=C(Cl)C=[N+]([O-])C=C3Cl)C4=CC=C(NS(=O)(C)=O)C(OCC5CC5)=C4
Molecular Formula
C30H30Cl2F2N2O8S
Molecular Weight
687.54
Precautions
H302, H315, H319
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-19929/Tanimilast-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-19929/Tanimilast-SDS-MedChemExpress.pdf
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
PDE4
CAS Number
[1239278-59-1]
Available Sizes
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