COG 133

COG 133 is a fragment of Apolipoprotein E (APOE) peptide. COG 133 competes with the ApoE holoprotein for binding the LDL receptor, with potent anti-inflammatory and neuroprotective effects. COG 133 is also a nAChR antagonist with an IC50 of 445 nM[1][2].

Product Specifications

CAS Number

[514200-66-9]

UNSPSC

12352209

Target

Apolipoprotein; nAChR

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cog-133.html

Purity

98.72

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

[C@H](CC1=CN=CN1)(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(N)=O)=O)CC(C)C)=O)CCCNC(=N)N)=O)CCCCN)=O)CCCNC(=N)N)=O)CC(C)C)=O)CCCCN)=O)CCCNC(=N)N)=O)CC(C)C)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC(C)C)NC(C)=O)=O)CCCNC(=N)N)=O)C(C)C)=O)CCCNC(=N)N)=O)CC(C)C)=O)C)=O)CO)=O

Molecular Formula

C97H181N37O19

Molecular Weight

2169.71

References & Citations

[1]Orleâncio Gomes R Azevedo, et al. Apolipoprotein E COG 133 mimetic peptide improves 5-fluorouracil-induced intestinal mucositis. BMC Gastroenterol. 2012 Jul 13;12:35.|[2]Elaine A Gay, et al. Apolipoprotein E-derived peptides block alpha7 neuronal nicotinic acetylcholine receptors expressed in xenopus oocytes. J Pharmacol Exp Ther. 2006 Feb;316 (2) :835-42.|[3]Huachun Cui, et al. Monocyte-derived alveolar macrophage apolipoprotein E participates in pulmonary fibrosis resolution. JCI Insight. 2020 Mar 12;5 (5) :e134539.