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AVE1231

AVE1231 (A293) is a dual-pore potassium channel TASK-1 inhibitor. AVE1231 blocks carbamoylcholine chloride (HY-B1208) -activated IKACh (IC50=8.4 μM) . AVE1231 can be used in the study of arrhythmias and atrial fibrillation[1][2].

Product Specifications

CAS Number

[767334-89-4]

Product Name Alternative

A293

UNSPSC

12352005

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ave1231.html

Purity

98.61

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H](C1=CC=C(OC)N=C1)CC)C2=CC=CC=C2NS(=O)(CCCC)=O

Molecular Formula

C20H27N3O4S

Molecular Weight

405.51

References & Citations

[1]Wiedmann F, et al. Identification of the A293 (AVE1231) binding site in the cardiac two-pore-domain potassium channel TASK-1: a common low affinity antiarrhythmic drug binding site[J]. Cellular Physiology & Biochemistry (Cell Physiol Biochem Press GmbH & Co. KG), 2019, 52 (5) .|[2]Wirth K J, et al. In vitro and in vivo effects of the atrial selective antiarrhythmic compound AVE1231[J]. Journal of cardiovascular pharmacology, 2007, 49 (4) : 197-206.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-126486/AVE1231-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-126486/AVE1231-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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