8(S)-HETE
Product Specifications
UNSPSC Description
8(S)-HETE (8(S)-Hydroxyeicosatetraenoic acid) is a major lipoxygenase product in PMA-treated murine epidermis. It activates mouse keratinocyte protein kinase C with an IC50 of 100 μM. 8(S)-HETE also activates PPARα selectively at concentrations as low as 0.3 μM. Stereochemical assignment of the (S) enantiomer is based on comparison of chiral HPLC retention times to published results.
Target Antigen
PPAR
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/8_S_-HETE.html
Smiles
CCCCC/C=C\C/C=C/C=C\[C@H](C/C=C\CCCC(O)=O)O
Molecular Weight
320.47
References & Citations
[1]Hughes, et al. Investigation of the mechanism of biosynthesis of 8-hydroxyeicosatetraenoic acid in mouse skin. Biochim. Biophys. Acta 1081(3), 347-354 (1991).
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-112653/8-S-HETE-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-112653/
Clinical Information
No Development Reported
CAS Number
98462-03-4
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS571097-01 0.2 mg
Mouse anti Human IgG2 (Fc subclass specific), conjugated with TRITC
Ask
View Details 
MBS571097-02 5x 0.2 mg
Mouse anti Human IgG2 (Fc subclass specific), conjugated with TRITC
Ask
View Details 