Motolimod

Motolimod (VTX-2337; VTX-378) is a selective Toll-like receptor 8 (TLR8) agonist, with an EC50 of approximately 100 nM.

Product Specifications

CAS Number

[926927-61-9]

Product Name Alternative

VTX-2337; VTX-378

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Motolimod.html

Concentration

10mM

Purity

98.98

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(C1=CC2=CC=C(C3=CC=C(C(N4CCCC4)=O)C=C3)C=C2N=C(N)C1)N(CCC)CCC

Molecular Formula

C28H34N4O2

Molecular Weight

458.60

Precautions

H302, H315, H319, H335

References & Citations

[1]Lu H, et al. VTX-2337 is a novel TLR8 agonist that activates NK cells and augments ADCC. Clin Cancer Res. 2012 Jan 15;18 (2) :499-509.|[2]Dietsch GN, et al. Coordinated Activation of Toll-Like Receptor8 (TLR8) and NLRP3 by the TLR8 Agonist, VTX-2337, Ignites Tumoricidal Natural Killer Cell Activity. PLoS One. 2016 Feb 29;11 (2) :e0148764.