Volagidemab
Volagidemab is an antagonistic glucagon receptor (GCGR) monoclonal antibody (mAb) . Volagidemab can be used in the research of type 1 diabetes (T1D) [1][2].
Product Specifications
CAS Number
[1233956-13-2]
Product Name Alternative
REMD-477; AMG-477
UNSPSC
12352203
Target
GCGR
Type
Inhibitory Antibodies
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/volagidemab.html
Purity
99.0
Solubility
10 mM in DMSO
Smiles
[Volagidemab]
Molecular Weight
(147.02 kDa)
References & Citations
[1]Pettus J, et al. Glucagon receptor antagonist volagidemab in type 1 diabetes: a 12-week, randomized, double-blind, phase 2 trial. Nat Med. 2022 Oct;28 (10) :2092-2099. |[2]Wang MY, et al. Glucagon receptor antibody completely suppresses type 1 diabetes phenotype without insulin by disrupting a novel diabetogenic pathway. Proc Natl Acad Sci U S A. 2015 Feb 24;112 (8) :2503-8.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 2
Available Sizes
Curated Selection
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