Sovilnesib
Sovilnesib (AMG 650) is a potent, orally active kinesin-like protein KIF18A inhibitor with an IC50 value of 0.071 μM. Sovilnesib can be used for the research of cancer[1][2].
Product Specifications
CAS Number
[2410796-79-9]
Product Name Alternative
AMG 650
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Kinesin; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sovilnesib.html
Purity
99.90
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=NC(N2CCC(F)(F)CC2)=NC(C)=C1)C3=CC=C(NS(=O)(CCO)=O)C=C3N(CC4)CCC54CC5
Molecular Formula
C26H34F2N6O4S
Molecular Weight
564.65
Precautions
H302, H315, H319
References & Citations
[1]Payton MN, et, al. Kif18a inhibitors for treatment of neoplastic diseases. WO2021211549|[2]Tamayo NA, et, al. Kif18a inhibitors. WO2020132648.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
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