MR-L2

MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4), activates representative PDE4 long-isoform variants (PDE4A4, PDE4B1, PDE4C3, PDE4D5) . MR-L2 suppresses PGE2-induced MDCK cell cyst formation with an EC50 of 1.2 μM[1].

Product Specifications

CAS Number

[2374703-19-0]

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mr-l2.html

Purity

98.63

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

ClC1=C(F)C=C(C2=NN(CC(NCC3=CC(Cl)=CC(Cl)=C3)=O)C(CC)=N2)C=C1

Molecular Formula

C19H16Cl3FN4O

Molecular Weight

441.71

References & Citations

[1]Omar F, et al. Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases. Proc Natl Acad Sci U S A. 2019 Jul 2;116 (27) :13320-13329.