LK-2
LK-2 is an antagonist for ASIC1a with a Kd of 1.9 μM. LK-2 reduces glutamate-induced ASIC1a current-enhancement with an IC50 of 6.6 μM. LK-2 exhibits neuroprotective efficacy in mouse ischemic stroke model, with improved motor and coordination skills. LK-2 is blood-brain barrier (BBB) penetrable[1].
Product Specifications
CAS Number
[2649762-09-2]
UNSPSC
12352005
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lk-2.html
Purity
98.83
Solubility
H2O : 50 mg/mL (ultrasonic)
Smiles
OP(C(C1=CC=CC=C1)N2CC(C(O)=O)NCC2)(O)=O
Molecular Formula
C12H17N2O5P
Molecular Weight
300.25
References & Citations
[1]Lai K, et al., Glutamate acts on acid-sensing ion channels to worsen ischaemic brain injury. Nature. 2024 Jul;631 (8022) :826-834.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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