MAL3-101

MAL3-101 is a potent HSP70 allosteric inhibitor. MAL3-101 inhibits HSP70 ATPase activity by blocking Hsp40 co-chaperone interaction. MAL3-101 can be used for researching muscle invasive bladder cancer (MIBC) [1].

Product Specifications

CAS Number

[831217-40-4]

UNSPSC

12352005

Target

HSP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mal3-101.html

Purity

98.22

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC(N(C(NC1C2=CC=C(C3=CC=CC=C3)C=C2)=O)CCCCCC(N(CCCCCC)C(C(NCCCC)=O)C4=CC=C(C(C(OC)=O)=C4)OCC(OC)=O)=O)=C1C(OCC5=CC=CC=C5)=O

Molecular Formula

C54H66N4O10

Molecular Weight

931.12

References & Citations

[1]Prince T, et al. Dual targeting of HSP70 does not induce the heat shock response and synergistically reduces cell viability in muscle invasive bladder cancer. Oncotarget. 2018 Aug 24;9 (66) :32702-32717.