4-Hydroxytolbutamide

4-Hydroxytolbutamide (Hydroxytolbutamide) is a metabolite of Tolbutamide. 4-Hydroxytolbutamide is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic[1][2].

Product Specifications

CAS Number

[5719-85-7]

Product Name Alternative

Hydroxytolbutamide

UNSPSC

12352005

Hazard Statement

H225, H302+H312+H332, H319

Target

Autophagy; Potassium Channel

Type

Reference compound

Related Pathways

Autophagy; Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/4-hydroxytolbutamide.html

Purity

99.69

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=S(C1=CC=C(CO)C=C1)(NC(NCCCC)=O)=O

Molecular Formula

C12H18N2O4S

Molecular Weight

286.35

Precautions

H225, H302+H312+H332, H319

References & Citations

[1] Hansen LL, et al. Quantitative determination of tolbutamide and its metabolites in human plasma and urine by high-performance liquid chromatography and UV detection. Ther Drug Monit. 1999 Dec;21 (6) :664-71.|[2]Yuan R, et al. Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions. Drug Metab Dispos. 2002 Dec;30 (12) :1311-9.