Beta-asarone

Beta-asarone is an orally active and BBB-penetrable anti-inflammatory agent and neuroprotective agent, which is the major ingredient of Acorus tatarinowii Schott. Beta-asarone can protect nerve cells from apoptosis and autophagy, inhibit expression of α-synuclein, as well as myocardial protection. Beta-asarone can be used in the study of neurological and cardiovascular diseases[1][2][3][4].

Product Specifications

CAS Number

[5273-86-9]

UNSPSC

12352005

Hazard Statement

H302

Target

α-synuclein

Type

Natural Products

Related Pathways

Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/beta-asarone.html

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C/C=C\C1=C(OC)C=C(OC)C(OC)=C1

Molecular Formula

C12H16O3

Molecular Weight

208.25

Precautions

H302

References & Citations

[1]Zhang QS, et al. Beta-asarone protects against MPTP-induced Parkinson's disease via regulating long non-coding RNA MALAT1 and inhibiting α-synuclein protein expression. Biomed Pharmacother. 2016 Oct;83:153-159.|[2]Xue Z, et al. Beta-asarone attenuates amyloid beta-induced autophagy via Akt/mTOR pathway in PC12 cells. Eur J Pharmacol. 2014 Oct 15;741:195-204.|[3]Liu J, et al. Beta-asarone attenuates neuronal apoptosis induced by Beta amyloid in rat hippocampus. Yakugaku Zasshi. 2010 May;130 (5) :737-46.|[4]Xiao B, et al. Beta-Asarone Alleviates Myocardial Ischemia-Reperfusion Injury by Inhibiting Inflammatory Response and NLRP3 Inflammasome Mediated Pyroptosis. Biol Pharm Bull. 2020 Jul 1;43 (7) :1046-1051.