Acoltremon

Acoltremon (WS-12; AR-15512) is a potent and selective TRPM8 agonist, the menthol derivative, as a cooling agent. Acoltremon shows analgesic effect, and can be used in chronic neuropathic pain research[1][2].

Product Specifications

CAS Number

[68489-09-8]

Product Name Alternative

WS-12; AR-15512; AVX-012

UNSPSC

12352005

Hazard Statement

H410

Target

TRP Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/acoltremon.html

Purity

99.13

Solubility

DMSO : 20 mg/mL (ultrasonic)

Smiles

O=C([C@H]1[C@H](C(C)C)CC[C@@H](C)C1)NC2=CC=C(OC)C=C2

Molecular Formula

C18H27NO2

Molecular Weight

289.41

Precautions

H410

References & Citations

[1]Beck B, et al. Prospects for prostate cancer imaging and therapy using high-affinity TRPM8 activators. Cell Calcium. 2007 Mar;41 (3) :285-94.|[2]Ma S, et al. Menthol derivative WS-12 selectively activates transient receptor potential melastatin-8 (TRPM8) ion channels. Pak J Pharm Sci. 2008 Oct;21 (4) :370-8.